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KMID : 1039420190530040244
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 4 p.244 ~ p.252
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Prognostic Significance of CD109 Expression in Patients with Ovarian Epithelial Cancer
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Kim So-Young
Choi Kyung-Un
Hwang Chung-Su
Lee Hyung-Jung
Lee Jung-Hee
Shin Dong-Hoon
Kim Jee-Yeon
Sol Mee-Young
Kim Jae-Ho
Kim Ki-Hyung
Suh Dong-Soo
Kwon Byung-Su
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Abstract
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Background: Ovarian epithelial cancer (OEC) is the second-most common gynecologic malignancy. CD109 expression is elevated in human tumor cell lines and carcinomas. A previous study showed that CD109 expression is elevated in human tumor cell lines and CD109 plays a role in cancer progression. Therefore, this study aimed to determine whether CD109 is expressed in OEC and can be useful in predicting the prognosis.
Methods: Immunohistochemical staining for CD109 and reverse transcription-quantitative polymerase chain reaction was performed. Then we compared CD109 expression and chemoresistance, overall survival, and recurrence-free survival of OEC patients. Chemoresistance was evaluated by dividing into good-response group and poor-response group by the time to recurrence after chemotherapy.
Results: CD109 expression was associated with overall survival (p = .020), but not recurrence-free survival (p = .290). CD109 expression was not an independent risk factor for overall survival due to its reliability (hazard ratio, 1.58; p = .160; 95% confidence interval, 0.82 to 3.05), although we found that CD109 positivity was related to chemoresistance. The poor-response group showed higher rates of CD109 expression than the good-response group (93.8% vs 66.7%, p = .047). Also, the CD109 mRNA expression level was 2.88 times higher in the poor-response group as compared to the good-response group (p = .001).
Conclusions: Examining the CD109 expression in patients with OEC may be helpful in predicting survival and chemotherapeutic effect.
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KEYWORD
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Ovarian epithelial carcinoma, CD109, Prognosis
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